Which group of individuals is at higher risk for CRE infections?

Critically ill patients are at a higher risk for Carbapenem-resistant Enterobacteriaceae (CRE) infections due to several factors associated with their health status and medical interventions. These patients often have weakened immune systems and may be experiencing one or more comorbidities that compromise their ability to fight infections effectively. In addition, critically ill patients frequently require invasive medical procedures, such as catheterizations or mechanical ventilation, which create pathways for bacteria to enter the body.

Furthermore, these individuals are often in hospital settings where CRE bacteria are more prevalent, particularly in intensive care units where antibiotic use is extensive. The exposure to broad-spectrum antibiotics can lead to the development of resistant organisms, including CRE. As a result, the combination of a compromised immune system, exposure to invasive techniques, and a hospital environment significantly increases the risk of CRE infections in critically ill patients.

In contrast, healthy adults, young children, and pregnant women generally do not face the same level of exposure to risk factors associated with CRE infection, such as prolonged hospital stays and invasive devices, making them less susceptible compared to critically ill patients.